Selected Publications:

  1. Liu, Q., Huang, B., Guiberson, N., Chen, S., Zhu, D., Ma, G., Ma, X., Crittenden, J.R., Yu, J., Graybiel, A, M., Dawson, T.M., Dawson, V.L., Xiong, Y. (2024) CalDAG-GEFI acts as a Guanine Nucleotide Exchange Factor for LRRK2 to regulate LRRK2 function and neurodegeneration. Science Advances (Accepted )
  2. Xiong, Y., Yu, J. (2024) LRRK2 in Parkinson’s disease: Upstream regulation and Therapeutic targeting.  Trends Mol. Med. Aug 16:S1471-4914(24)00189-8. doi: 10.1016/j.molmed.2024.07.003 
  3. Liu, Q., Zhu, D., Li, N., Chen, S., Hu, L., Yu, J., Xiong, Y. (2023) Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson’s disease. The EMBO Journal e113410 doi: 10.15252/embj.2022113410 
  4. Hu, L., Brichalli, W., Li, N., Chen, S., Cheng, Y., Liu, Q., Xiong, Y.*, Yu, J.*. (2022) Myotubularin functions through actomyosin to interact with the Hippo pathway. EMBO Reports  e55851 (*corresponding author).
  5. Liu, Q., Bautista-Gomez, J., Higgins, D.A., Yu, J. *, Xiong, Y.* (2021) LRRK2 regulates an AP2M1 phosphorylation cycle to mediate endocytosis and dopaminergic neurodegeneration. Sci. Signal. 14(693): eabg3555 (*corresponding author)
  6. Xiong, Y.*, Yu, J.* (2020) Linking the leucine-rich repeat kinase 2 (LRRK2) gene, animal models and Parkinson’s disease. The Neuroscience of Parkinson’s disease: Volume 2: Genetics, Neurology, Behavior, and Diet in Parkinson’s Disease (Elsevier, ISBN: 9780128159507).  (Book chapter, *corresponding author)
  7. Li, N., Liu, Q., Xiong, Y*, Yu, J.*. (2019) Headcase and Unkempt regulate tissue growth and cell cycle progression in response to nutrient restriction. Cell Reports, 26,733-747 (*corresponding author)
  8. Xiong, Y.*, Yu, J.* (2018) Modeling Parkinson’s disease in Drosophila: What have we learned for dominant traits? Front Neurol. Apr 9; 9:228. (*corresponding author)
  9. Yu, J., Pan, D. (2018). Validating upstream regulators of Yorkie activity in Hippo signaling through scalloped-based genetic epistasis. Development 145(4): dev157545.
  10. Maoxu Ge, Hong Liu, Yixuan Zhang, Naren Li, Shuangshuang Zhao, Wuli Zhao, Yongzhan Zhen, Jianzhong Yu, Hongwei He, Rongguang Shao (2017). The anti-hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes-associated protein and transcriptional enhancer factor D2 complexand stimulating autophagy. British Journal of Pharmacology 174(10):1147-1160.
  11. Chan P, Han X, Zheng B, DeRan M, Yu J, Jarugumilli GK, Deng H, Pan D, Luo X, Wu X (2016). Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Nat Chem Biol. 12(4):282-9
  12. Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D (2016). Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell 164(3):406-19.
  13. Deng H, Wang W, Yu J, Zheng Y, Qing Y, Pan D (2015). Spectrin regulates Hippo signaling by modulating cortical actomyosin activity. Elife 31: 4. doi: 10.7554/eLife.06567.
  14. Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D (2013). Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell 154(6):1342-55.
  15. Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D, Luo X (2013). Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure 21(10):1757-68.
  16. Koontz LM, Liu-Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, Chen Q, Wu S, Pan D (2013). The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Developmental Cell 25(4):388-401.
  17. Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, Wu S, Pan D (2010). The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc. Natl. Acad. Sci. USA, 107(23):10532-7
  18. Tian W, Yu J, Tomchick D, Pan D, Luo X (2010). Structural and Functional Analysis of the YAP-binding Domain of Human TEAD2.  Proc. Natl. Acad. Sci. USA, 107(16):7293-8
  19. Yu J, Zheng Y, Dong J, Klusza S, Deng WM, Pan D (2010). Kibra functions as a tumor suppressor protein that regulates hippo signaling in conjunction with Merlin and expanded. Developmental Cell 18(2):288-99.
  20. Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massagué J (2009).  Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139(4):757-69.
  21. Yu J, Poulton J, Huang YC, Deng WM (2008). The Hippo Pathway Promotes Notch Signaling in Regulation of Cell Differentiation, Proliferation, and Oocyte Polarity. PLoS ONE. 3(3): e1761.