|Address:||Pharmacy and Biology Building|
75 N. Eagleville Rd
Storrs, CT 06269-3156
The long-term research goal of my laboratory is to understand: 1) the molecular mechanisms of organ size control, with a specific emphasis on the molecular regulation of the Hippo pathway and mTOR pathway. 2) the molecular mechanisms of neurological disorders, with a specific emphasis on Charcot-Marie-Tooth type 4B1 (CMT4B1) disease and Parkinson’s disease (PD). To achieve these goals, we use a multidisciplinary approach employing molecular, cellular, and biochemical experimental techniques in combination with fly genetics and mammalian model systems. Briefly, we start with unbiased genetic screens for novel candidate genes. We then use a combination of genetic and biochemical approaches to study the function of these genes. Moreover, we investigate their conserved function in mammalian systems using cell culture and mouse models.
We are currently seeking motivated undergraduate, graduate students and postdocs to join our team.